METODO DI BELLA > PRINCIPI ATTIVI > Melatonina > Intracellular prooxidant activity of melatonin induces a survival pathway involving NF-kappaB activation.

 
Intracellular prooxidant activity of melatonin induces a survival pathway involving NF-kappaB activation. di Cristofanon S, Uguccioni F, Cerella C, Radogna F, Dicato M, Ghibelli L, Diederich M.
 
 
Data: 06/05/2011
Tipologia: DOCUMENTAZIONE SCIENTIFICA
Lingua: Inglese
Pubblicazione: Ann N Y Acad Sci
Anno: 2009
Fonte: Ann N Y Acad Sci. 2009 Aug;1171:472-8
 
 
Descrizione:

We have shown that melatonin exerts a prooxidant activity in U937 cells, a tumor human promonocytic cell line. (1) Here we show that melatonin induces a strong canonical activation of NF-kappaB, inducing IkappaBalpha degradation and the consequential nuclear translocation of p50/p65 subunits. The timing of NF-kappaB activation overlaps with the timing of reactive oxygen species (ROS) production due to melatonin. Overexpression of dominant-negative IkappaB, which prevents a possible NF-kappaB activation, transformed melatonin in a proapoptotic molecule. These data indicate for the first time that melatonin can trigger NF-kappaB activation and might suggest a possible role for ROS induced by melatonin. Results indicate a possible involvement in the survival pathway of melatonin-generated ROS as secondary messengers.

 
 
 

 

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