METODO DI BELLA > PRINCIPI ATTIVI > Melatonina > Melatonin suppresses AOM/DSS-induced large bowel oncogenesis in rats.

 
Melatonin suppresses AOM/DSS-induced large bowel oncogenesis in rats. di Tanaka T, Yasui Y, Tanaka M, Tanaka T, Oyama T, Rahman KM.
 
 
Data: 06/05/2011
Tipologia: DOCUMENTAZIONE SCIENTIFICA
Lingua: Inglese
Anno: 2009
Fonte: Chem Biol Interact. 2009 Jan 27;177(2):128-36.
 
 
Descrizione:

The inhibitory effects of exogenous melatonin (MEL) on colon oncogenesis were investigated using an azoxymethane (AOM)/dextran sodium sulfate (DSS) rat model. Male F344 rats initiated with a single intraperitoneal injection of AOM (20mg/kg bw) were promoted by 1% (w/v) DSS in drinking water for 7 days. They were then given 0.4, 2 or 10ppm MEL in drinking water for 17 weeks. At week 20, the development of colonic adenocarcinoma was significantly inhibited by the administration with MEL dose-dependently. MEL exposure modulated the mitotic and apoptotic indices in the colonic adenocarcinomas that developed and lowered the immunohistochemical expression of nuclear factor kappa B, tumor necrosis factor alpha, interleukin-1beta and STAT3 in the epithelial malignancies. These results may indicate the beneficial effects of MEL on colitis-related colon carcinogenesis and a potential application for inhibiting colorectal cancer development in the inflamed colon.

 
 
 

 

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